![](/images/graphics-bg.png)
Preoperative RAS Mutational Analysis Is of Great Value in Predicting Follicular Variant of Papillary Thyroid Carcinoma
Joint Authors
Oh, Seo Young
Kim, Wook Youn
Hwang, Tae Sook
Yang, Jung-Hyun
Han, Hye Seung
Lim, So Dug
Kim, Wan-Seop
Yoo, Young Bum
Park, Kyoung Sik
Kim, Suk Kyeong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Follicular variant of papillary thyroid carcinoma (FVPTC), particularly the encapsulated subtype, often causes a diagnostic dilemma.
We reconfirmed the molecular profiles in a large number of FVPTCs and investigated the efficacy of the preoperative mutational analysis in indeterminate thyroid nodules.
BRAF V600E/K601E and RAS mutational analysis was performed on 187 FVPTCs.
Of these, 132 (70.6%) had a point mutation in one of the BRAF V600E (n=57), BRAF K601E (n=11), or RAS (n=64) genes.
All mutations were mutually exclusive.
The most common RAS mutations were at NRAS codon 61.
FNA aspirates from 564 indeterminate nodules were prospectively tested for BRAF and RAS mutation and the surgical outcome was correlated with the mutational status.
Fifty-seven and 47 cases were positive for BRAF and RAS mutation, respectively.
Twenty-seven RAS-positive patients underwent surgery and all except one patient had FVPTC.
The PPV and accuracy of RAS mutational analysis for predicting FVPTC were 96% and 84%, respectively.
BRAF or RAS mutations were present in more than two-thirds of FVPTCs and these were mutually exclusive.
BRAF mutational analysis followed by N, H, and KRAS codon 61 mutational analysis in indeterminate thyroid nodules would streamline the management of patients with malignancies, mostly FVPTC.
American Psychological Association (APA)
Hwang, Tae Sook& Kim, Wook Youn& Han, Hye Seung& Lim, So Dug& Kim, Wan-Seop& Yoo, Young Bum…[et al.]. 2015. Preoperative RAS Mutational Analysis Is of Great Value in Predicting Follicular Variant of Papillary Thyroid Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056419
Modern Language Association (MLA)
Hwang, Tae Sook…[et al.]. Preoperative RAS Mutational Analysis Is of Great Value in Predicting Follicular Variant of Papillary Thyroid Carcinoma. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056419
American Medical Association (AMA)
Hwang, Tae Sook& Kim, Wook Youn& Han, Hye Seung& Lim, So Dug& Kim, Wan-Seop& Yoo, Young Bum…[et al.]. Preoperative RAS Mutational Analysis Is of Great Value in Predicting Follicular Variant of Papillary Thyroid Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056419