Assessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity
Joint Authors
Rewers, Marian
Lamb, Molly M.
Barón, Anna
Crume, Tessa L.
Sontag, Marci K.
Norris, Jill M.
Kroehl, Miranda
Frederiksen, Brittni N.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Type 1 diabetes (T1D), a chronic autoimmune disease, is often preceded by a preclinical phase of islet autoimmunity (IA) where the insulin-producing beta cells of the pancreas are destroyed and circulating autoantibodies can be detected.
The goal of this study was to demonstrate methods for identifying exposures that differentially influence the disease process at certain ages by assessing age-related heterogeneity.
The Diabetes Autoimmunity Study in the Young (DAISY) has followed 2,547 children at increased genetic risk for T1D from birth since 1993 in Denver, Colorado, 188 of whom developed IA.
Using the DAISY population, we evaluated putative determinants of IA, including non-Hispanic white (NHW) ethnicity, maternal age at birth, and erythrocyte membrane n-3 fatty acid (FA) levels, for age-related heterogeneity.
A supremum test, weighted Schoenfeld residuals, and restricted cubic splines were used to assess nonproportional hazards, that is, an age-related association of the exposure with IA risk.
NHW ethnicity, maternal age, and erythrocyte membrane n-3 FA levels demonstrated a significant age-related association with IA risk.
Assessing heterogeneity in disease etiology enables researchers to identify associations that may lead to better understanding of complex chronic diseases.
American Psychological Association (APA)
Frederiksen, Brittni N.& Kroehl, Miranda& Barón, Anna& Lamb, Molly M.& Crume, Tessa L.& Sontag, Marci K.…[et al.]. 2015. Assessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056450
Modern Language Association (MLA)
Frederiksen, Brittni N.…[et al.]. Assessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056450
American Medical Association (AMA)
Frederiksen, Brittni N.& Kroehl, Miranda& Barón, Anna& Lamb, Molly M.& Crume, Tessa L.& Sontag, Marci K.…[et al.]. Assessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056450