Recovering Drug-Induced Apoptosis Subnetwork from Connectivity Map Data
Joint Authors
Yu, Jiyang
Putcha, Preeti
Silva, Jose M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The Connectivity Map (CMAP) project profiled human cancer cell lines exposed to a library of anticancer compounds with the goal of connecting cancer with underlying genes and potential treatments.
Since the therapeutic goal of most anticancer drugs is to induce tumor-selective apoptosis, it is critical to understand the specific cell death pathways triggered by drugs.
This can help to better understand the mechanism of how cancer cells respond to chemical stimulations and improve the treatment of human tumors.
In this study, using CMAP microarray data from breast cancer cell line MCF7, we applied a Gaussian Bayesian network modeling approach and identified apoptosis as a major drug-induced cellular-pathway.
We then focused on 13 apoptotic genes that showed significant differential expression across all drug-perturbed samples to reconstruct the apoptosis network.
In our predicted subnetwork, 9 out of 15 high-confidence interactions were validated in the literature, and our inferred network captured two major cell death pathways by identifying BCL2L11 and PMAIP1 as key interacting players for the intrinsic apoptosis pathway and TAXBP1 and TNFAIP3 for the extrinsic apoptosis pathway.
Our inferred apoptosis network also suggested the role of BCL2L11 and TNFAIP3 as “gateway” genes in the drug-induced intrinsic and extrinsic apoptosis pathways.
American Psychological Association (APA)
Yu, Jiyang& Putcha, Preeti& Silva, Jose M.. 2015. Recovering Drug-Induced Apoptosis Subnetwork from Connectivity Map Data. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056451
Modern Language Association (MLA)
Yu, Jiyang…[et al.]. Recovering Drug-Induced Apoptosis Subnetwork from Connectivity Map Data. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056451
American Medical Association (AMA)
Yu, Jiyang& Putcha, Preeti& Silva, Jose M.. Recovering Drug-Induced Apoptosis Subnetwork from Connectivity Map Data. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056451