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The Sarcomeric M-Region: A Molecular Command Center for Diverse Cellular Processes
Joint Authors
Kontrogianni-Konstantopoulos, Aikaterini
Hu, Li-Yen R.
Ackermann, Maegen A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-15
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
The sarcomeric M-region anchors thick filaments and withstands the mechanical stress of contractions by deformation, thus enabling distribution of physiological forces along the length of thick filaments.
While the role of the M-region in supporting myofibrillar structure and contractility is well established, its role in mediating additional cellular processes has only recently started to emerge.
As such, M-region is the hub of key protein players contributing to cytoskeletal remodeling, signal transduction, mechanosensing, metabolism, and proteasomal degradation.
Mutations in genes encoding M-region related proteins lead to development of severe and lethal cardiac and skeletal myopathies affecting mankind.
Herein, we describe the main cellular processes taking place at the M-region, other than thick filament assembly, and discuss human myopathies associated with mutant or truncated M-region proteins.
American Psychological Association (APA)
Hu, Li-Yen R.& Ackermann, Maegen A.& Kontrogianni-Konstantopoulos, Aikaterini. 2015. The Sarcomeric M-Region: A Molecular Command Center for Diverse Cellular Processes. BioMed Research International،Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1056470
Modern Language Association (MLA)
Hu, Li-Yen R.…[et al.]. The Sarcomeric M-Region: A Molecular Command Center for Diverse Cellular Processes. BioMed Research International No. 2015 (2015), pp.1-25.
https://search.emarefa.net/detail/BIM-1056470
American Medical Association (AMA)
Hu, Li-Yen R.& Ackermann, Maegen A.& Kontrogianni-Konstantopoulos, Aikaterini. The Sarcomeric M-Region: A Molecular Command Center for Diverse Cellular Processes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1056470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056470