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Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential
Joint Authors
Malagobadan, Sharan
Nagoor, Noor Hasima
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dysregulation of microRNAs (miRNAs) has been implicated in almost every known survival mechanisms utilized by cancer cells.
One of such mechanisms, anoikis resistance, plays a pivotal role in enabling metastasis by allowing cancer cells to circumvent cell death induced by lack of attachment.
Understanding how miRNAs regulate the various anoikis pathways has become the research question of increasing number of studies published in the past years.
Through these studies, a growing list of miRNAs has been identified to be important players in promoting either anoikis or resistance to anoikis.
In this review, we will be focusing on these miRNAs and how the findings from those studies can contribute to novel therapeutic strategies against cancer progression.
We will be examining miRNAs that have been found to promote anoikis sensitivity in numerous cancer types followed by miRNAs that inhibit anoikis.
In addition, we will also be taking a look at major signaling pathways involved in the action of the each of these miRNAs to gain a better understanding on how miRNAs regulate anoikis.
American Psychological Association (APA)
Malagobadan, Sharan& Nagoor, Noor Hasima. 2015. Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056479
Modern Language Association (MLA)
Malagobadan, Sharan& Nagoor, Noor Hasima. Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056479
American Medical Association (AMA)
Malagobadan, Sharan& Nagoor, Noor Hasima. Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056479