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Analysis of Chromosome 17 miRNAs and Their Importance in Medulloblastomas
Joint Authors
López-Ochoa, Sebastian
Ramírez-García, Marina
Castro-Sierra, Eduardo
Arenas-Huertero, Francisco
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are small sequences of nucleotides that regulate posttranscriptionally gene expression.
In recent years they have been recognized as very important general regulators of proliferation, differentiation, adhesion, cell death, and others.
In some cases, the characteristic presence of miRNAs reflects some of the cellular pathways that may be altered.
Particularly medulloblastomas (MB) represent entities that undergo almost characteristic alterations of chromosome 17: from loss of discrete fragments and isochromosomes formation to complete loss of one of them.
An analysis of the major loci on this chromosome revealed that it contains at least 19 genes encoding miRNAs which may regulate the development and differentiation of the brain and cerebellum.
miRNAs are regulators of real complex networks; they can regulate from 100 to over 300 messengers of various proteins.
In this review some miRNAs are considered to be important in MB studies.
Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634.
Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor.
In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.
American Psychological Association (APA)
López-Ochoa, Sebastian& Ramírez-García, Marina& Castro-Sierra, Eduardo& Arenas-Huertero, Francisco. 2015. Analysis of Chromosome 17 miRNAs and Their Importance in Medulloblastomas. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056484
Modern Language Association (MLA)
López-Ochoa, Sebastian…[et al.]. Analysis of Chromosome 17 miRNAs and Their Importance in Medulloblastomas. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056484
American Medical Association (AMA)
López-Ochoa, Sebastian& Ramírez-García, Marina& Castro-Sierra, Eduardo& Arenas-Huertero, Francisco. Analysis of Chromosome 17 miRNAs and Their Importance in Medulloblastomas. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056484