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The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats
Joint Authors
Jaworek, Andrzej K.
Bonior, Joanna
Pihut, M.
Ceranowicz, Piotr
Cieszkowski, Jakub
Warzecha, Zygmunt
Dembiński, Artur
Matuszyk, Aleksandra
Ceranowicz, Dagmara
Fyderek, Krzysztof
Gałązka, Krystyna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ghrelin has protective and therapeutic effects in the gut.
The aim of present studies was to investigate the effect of treatment with ghrelin on the development of colitis evoked by dextran sodium sulfate (DSS).
Methods.
Studies have been performed on rats.
Colitis was induced by adding 5% DSS to the drinking water for 5 days.
During this period animals were treated intraperitoneally twice a day with saline or ghrelin given at the dose of 8 nmol/kg/dose.
On the sixth day, animals were anesthetized and the severity of colitis was assessed.
Results.
Treatment with ghrelin during administration of DSS reduced the development of colitis.
Morphological features of colonic mucosa exhibited a reduction in the area and deep of mucosal damage.
Ghrelin reversed the colitis-induced decrease in blood flow, DNA synthesis, and superoxide dismutase activity in colonic mucosa.
These effects were accompanied by a decrease in the colitis-evoked increase in mucosal concentration of interleukin-1β and malondialdehyde.
Treatment with ghrelin reversed the DSS-induced reduction in body weight gain.
Conclusions.
Administration of ghrelin exhibits the preventive effect against the development of DSS-induced colitis.
This effect seems to be related to ghrelin’s anti-inflammatory and antioxidative properties.
American Psychological Association (APA)
Matuszyk, Aleksandra& Ceranowicz, Dagmara& Warzecha, Zygmunt& Ceranowicz, Piotr& Fyderek, Krzysztof& Gałązka, Krystyna…[et al.]. 2015. The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056486
Modern Language Association (MLA)
Matuszyk, Aleksandra…[et al.]. The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056486
American Medical Association (AMA)
Matuszyk, Aleksandra& Ceranowicz, Dagmara& Warzecha, Zygmunt& Ceranowicz, Piotr& Fyderek, Krzysztof& Gałązka, Krystyna…[et al.]. The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056486