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Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study
Joint Authors
Caers, Jo
Tangen, Jon-Magnus
Tierens, Anne
Binsfeld, Marilene
Olstad, Ole Kristoffer
Trøseid, Anne-Marie Siebke
Wang, Junbai
Tjønnfjord, Geir Erland
Hetland, Geir
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Forty patients with multiple myeloma scheduled to undergo high dose chemotherapy with autologous stem cell support were randomized in a double blinded fashion to receive adjuvant treatment with the mushroom extract AndoSan, containing 82% of Agaricus blazei Murrill (19 patients) or placebo (21 patients).
Intake of the study product started on the day of stem cell mobilizing chemotherapy and continued until the end of aplasia after high dose chemotherapy, a period of about seven weeks.
Thirty-three patients were evaluable for all study endpoints, while all 40 included patients were evaluable for survival endpoints.
In the leukapheresis product harvested after stem cell mobilisation, increased percentages of Treg cells and plasmacytoid dendritic cells were found in patients receiving AndoSan.
Also, in this group, a significant increase of serum levels of IL-1ra, IL-5, and IL-7 at the end of treatment was found.
Whole genome microarray showed increased expression of immunoglobulin genes, Killer Immunoglobulin Receptor (KIR) genes, and HLA genes in the Agaricus group.
Furthermore, AndoSan displayed a concentration dependent antiproliferative effect on mouse myeloma cells in vitro.
There were no statistically significant differences in treatment response, overall survival, and time to new treatment.
The study was registered with Clinicaltrials.gov NCT00970021.
American Psychological Association (APA)
Tangen, Jon-Magnus& Tierens, Anne& Caers, Jo& Binsfeld, Marilene& Olstad, Ole Kristoffer& Trøseid, Anne-Marie Siebke…[et al.]. 2015. Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056488
Modern Language Association (MLA)
Tangen, Jon-Magnus…[et al.]. Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056488
American Medical Association (AMA)
Tangen, Jon-Magnus& Tierens, Anne& Caers, Jo& Binsfeld, Marilene& Olstad, Ole Kristoffer& Trøseid, Anne-Marie Siebke…[et al.]. Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056488