Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study
Joint Authors
Rao, Hengyi
Xia, Wenqing
Wang, Shaohua
Spaeth, Andrea M.
Wang, Pin
Yang, Yue
Huang, Rong
Cai, Rongrong
Sun, Haixia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We aim to investigate whether decreased interhemispheric functional connectivity exists in patients with type 2 diabetes mellitus (T2DM) by using resting-state functional magnetic resonance imaging (rs-fMRI).
In addition, we sought to determine whether interhemispheric functional connectivity deficits associated with cognition and insulin resistance (IR) among T2DM patients.
We compared the interhemispheric resting state functional connectivity of 32 T2DM patients and 30 healthy controls using rs-fMRI.
Partial correlation coefficients were used to detect the relationship between rs-fMRI information and cognitive or clinical data.
Compared with healthy controls, T2DM patients showed bidirectional alteration of functional connectivity in several brain regions.
Functional connectivity values in the middle temporal gyrus (MTG) and in the superior frontal gyrus were inversely correlated with Trail Making Test-B score of patients.
Notably, insulin resistance (log homeostasis model assessment-IR) negatively correlated with functional connectivity in the MTG of patients.
In conclusion, T2DM patients exhibit abnormal interhemispheric functional connectivity in several default mode network regions, particularly in the MTG, and such alteration is associated with IR.
Alterations in interhemispheric functional connectivity might contribute to cognitive dysfunction in T2DM patients.
American Psychological Association (APA)
Xia, Wenqing& Wang, Shaohua& Spaeth, Andrea M.& Rao, Hengyi& Wang, Pin& Yang, Yue…[et al.]. 2015. Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056494
Modern Language Association (MLA)
Xia, Wenqing…[et al.]. Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056494
American Medical Association (AMA)
Xia, Wenqing& Wang, Shaohua& Spaeth, Andrea M.& Rao, Hengyi& Wang, Pin& Yang, Yue…[et al.]. Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056494