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Incidence and Prognostic Impact of DNMT3A Mutations in Korean Normal Karyotype Acute Myeloid Leukemia Patients
Joint Authors
Park, Sang Hyuk
Choi, Jae-Cheol
Yi, Jongyoun
Oh, Seung Hwan
Kim, In-Suk
Kim, Hyung-Hoi
Chang, Chulhun Ludgerus
Lee, Eun Yup
Song, Moo-Kon
Chung, Joo Seop
Kim, Shine Young
Shin, Ho-Jin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
DNA methyltransferase 3A (DNMT3A) mutation was recently introduced as a prognostic indicator in normal karyotype (NK) AML and we evaluated the incidence and prognostic impact of DNMT3A mutations in Korean NK AML patients.
Methods.
Total 67 NK AML patients diagnosed during the recent 10 years were enrolled.
DNMT3A mutations were analyzed by direct sequencing and categorized into nonsynonymous variations (NSV), deleterious mutations (DM), and R882 mutation based on in silico analysis results.
Clinical features and prognosis were compared with respect to DNMT3A mutation status.
Results.
Three novel (I158M, K219V, and E177V) and two known (R736H and R882H) NSVs were identified and the latter three were predicted as DMs.
DNMT3A NSVs, DMs, and R882 mutation were identified in 14.9%–17.9%, 10.3%–10.4%, and 7.5% of patients, respectively.
DNMT3A mutations were frequently detected in FLT3 ITD mutated patients (P = 0.054, 0.071, and 0.071 in NSV, DMs, and R882 mutation, resp.) but did not affect clinical features and prognosis significantly.
Conclusions.
Incidences of DNMT3A NSVs, DMs, and R882 mutation are 14.9%–17.9%, 10.3%–10.4%, and 7.5%, respectively, in Korean NK AML patients.
DNMT3A mutations are associated with FLT3 ITD mutations but do not affect clinical outcome significantly in Korean NK AML patients.
American Psychological Association (APA)
Park, Sang Hyuk& Choi, Jae-Cheol& Kim, Shine Young& Yi, Jongyoun& Oh, Seung Hwan& Kim, In-Suk…[et al.]. 2015. Incidence and Prognostic Impact of DNMT3A Mutations in Korean Normal Karyotype Acute Myeloid Leukemia Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056511
Modern Language Association (MLA)
Park, Sang Hyuk…[et al.]. Incidence and Prognostic Impact of DNMT3A Mutations in Korean Normal Karyotype Acute Myeloid Leukemia Patients. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056511
American Medical Association (AMA)
Park, Sang Hyuk& Choi, Jae-Cheol& Kim, Shine Young& Yi, Jongyoun& Oh, Seung Hwan& Kim, In-Suk…[et al.]. Incidence and Prognostic Impact of DNMT3A Mutations in Korean Normal Karyotype Acute Myeloid Leukemia Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056511