Detecting Key Genes Regulated by miRNAs in Dysfunctional Crosstalk Pathway of Myasthenia Gravis
Joint Authors
Cao, Yuze
Wang, Jianjian
Zhang, Huixue
Tian, Qinghua
Chen, Lixia
Ning, Shangwei
Liu, Peifang
Sun, Xuesong
Lu, Xiaoyu
Song, Chang
Zhang, Shuai
Xiao, Bo
Wang, Lihua
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Myasthenia gravis (MG) is a neuromuscular autoimmune disorder resulting from autoantibodies attacking components of the neuromuscular junction.
Recent studies have implicated the aberrant expression of microRNAs (miRNAs) in the pathogenesis of MG; however, the underlying mechanisms remain largely unknown.
This study aimed to identify key genes regulated by miRNAs in MG.
Six dysregulated pathways were identified through differentially expressed miRNAs and mRNAs in MG, and significant crosstalk was detected between five of these.
Notably, crosstalk between the “synaptic long-term potentiation” pathway and four others was mediated by five genes involved in the MAPK signaling pathway.
Furthermore, 14 key genes regulated by miRNAs were detected, of which six—MAPK1, RAF1, PGF, PDGFRA, EP300, and PPP1CC—mediated interactions between the dysregulated pathways.
MAPK1 and RAF1 were responsible for most of this crosstalk (80%), likely reflecting their central roles in MG pathogenesis.
In addition, most key genes were enriched in immune-related local areas that were strongly disordered in MG.
These results provide new insight into the pathogenesis of MG and offer new potential targets for therapeutic intervention.
American Psychological Association (APA)
Cao, Yuze& Wang, Jianjian& Zhang, Huixue& Tian, Qinghua& Chen, Lixia& Ning, Shangwei…[et al.]. 2015. Detecting Key Genes Regulated by miRNAs in Dysfunctional Crosstalk Pathway of Myasthenia Gravis. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056514
Modern Language Association (MLA)
Cao, Yuze…[et al.]. Detecting Key Genes Regulated by miRNAs in Dysfunctional Crosstalk Pathway of Myasthenia Gravis. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056514
American Medical Association (AMA)
Cao, Yuze& Wang, Jianjian& Zhang, Huixue& Tian, Qinghua& Chen, Lixia& Ning, Shangwei…[et al.]. Detecting Key Genes Regulated by miRNAs in Dysfunctional Crosstalk Pathway of Myasthenia Gravis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056514