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β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats
Joint Authors
Cuevas, Catherina A.
Tapia-Rojas, Cheril
Cespedes, Carlos
Vio, Carlos P.
Inestrosa, Nibaldo C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The mechanism of hypertension-induced renal fibrosis is not well understood, although it is established that high levels of angiotensin II contribute to the effect.
Since β -catenin signal transduction participates in fibrotic processes, we evaluated the contribution of β -catenin-dependent signaling pathway in hypertension-induced renal fibrosis.
Two-kidney one-clip (2K1C) hypertensive rats were treated with lisinopril (10 mg/kg/day for four weeks) or with pyrvinium pamoate (Wnt signaling inhibitor, single dose of 60 ug/kg, every 3 days for 2 weeks).
The treatment with lisinopril reduced the systolic blood pressure from 220 ± 4 in 2K1C rats to 112 ± 5 mmHg ( P < 0.05 ), whereas the reduction in blood pressure with pyrvinium pamoate was not significant (212 ± 6 in 2K1C rats to 170 ± 3 mmHg, P > 0.05 ).
The levels of collagen types I and III, osteopontin, and fibronectin decreased in the unclipped kidney in both treatments compared with 2K1C rats.
The expressions of β -catenin, p-Ser9-GSK-3beta, and the β -catenin target genes cyclin D1, c-myc, and bcl-2 significantly decreased in unclipped kidney in both treatments ( P < 0.05 ).
In this study we provided evidence that β -catenin-dependent signaling pathway participates in the renal fibrosis induced in 2K1C rats.
American Psychological Association (APA)
Cuevas, Catherina A.& Tapia-Rojas, Cheril& Cespedes, Carlos& Inestrosa, Nibaldo C.& Vio, Carlos P.. 2015. β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056519
Modern Language Association (MLA)
Cuevas, Catherina A.…[et al.]. β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1056519
American Medical Association (AMA)
Cuevas, Catherina A.& Tapia-Rojas, Cheril& Cespedes, Carlos& Inestrosa, Nibaldo C.& Vio, Carlos P.. β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056519