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Antimicrobial, Antioxidant, and Cytotoxic Properties of Vasicine Acetate Synthesized from Vasicine Isolated from Adhatoda vasica L.
Joint Authors
Ignacimuthu, Savarimuthu
Duraipandiyan, V.
Al-Dhabi, N. A.
Balachandran, C.
Sankar, C.
Balakrishna, K.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India.
The alkaloid Vasicine was isolated from ethanolic extract of the leaves of A.
vasica using column chromatography.
Vasicine acetate was obtained by acetylation of Vasicine.
Vasicine acetate exhibited good zone of inhibition against bacteria: 10 mm against E.
aerogenes, 10 mm against S.
epidermidis, and 10 mm against P.
aeruginosa.
Vasicine acetate showed minimum inhibitory concentration values against bacteria: M.
luteus (125 μg/mL), E.
aerogenes (125 μg/mL), S.
epidermidis (125 μg/mL), and P.
aeruginosa (125 μg/mL).
The radical scavenging activity of Vasicine acetate was the maximum at 1000 μg/mL (66.15%).
The compound showed prominent cytotoxic activity in vitro against A549 lung adenocarcinoma cancer cell line.
Quantification of Vasicine and Vasicine acetate by HPLC-DAD analysis showed their contents to be 0.2293% and 0.0156%, respectively, on dry weight basis of the leaves.
Vasicine acetate could be probed further in drug discovery programme.
American Psychological Association (APA)
Duraipandiyan, V.& Al-Dhabi, N. A.& Balachandran, C.& Ignacimuthu, Savarimuthu& Sankar, C.& Balakrishna, K.. 2015. Antimicrobial, Antioxidant, and Cytotoxic Properties of Vasicine Acetate Synthesized from Vasicine Isolated from Adhatoda vasica L.. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056524
Modern Language Association (MLA)
Duraipandiyan, V.…[et al.]. Antimicrobial, Antioxidant, and Cytotoxic Properties of Vasicine Acetate Synthesized from Vasicine Isolated from Adhatoda vasica L.. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056524
American Medical Association (AMA)
Duraipandiyan, V.& Al-Dhabi, N. A.& Balachandran, C.& Ignacimuthu, Savarimuthu& Sankar, C.& Balakrishna, K.. Antimicrobial, Antioxidant, and Cytotoxic Properties of Vasicine Acetate Synthesized from Vasicine Isolated from Adhatoda vasica L.. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056524