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Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury
Joint Authors
Huang, Kuo-Feng
Chen, Gunng-Shinng
Huang, Chien-Chu
Wang, Jia-Yi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome.
Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung.
Since pulmonary edema (PE) usually occurs in the TBI-induced ALI patients, we investigated the effects of a thaliporphine derivative, TM-1, on the expression of AQPs and histological outcomes in the lung following TBI in rats.
TM-1 administered (10 mg/kg, intraperitoneal injection) at 3 or 4 h after TBI significantly reduced the elevated mRNA expression and protein levels of AQP1 and AQP4 and diminished the wet/dry weight ratio, which reflects PE, in the lung at 8 and 24 h after TBI.
Postinjury TM-1 administration also improved histopathological changes at 8 and 24 h after TBI.
PE was accompanied with tissue pathological changes because a positive correlation between the lung injury score and the wet/dry weight ratio in the same animal was observed.
Postinjury administration of TM-1 improved ALI and reduced PE at 8 and 24 h following TBI.
The pulmonary-protective effect of TM-1 may be attributed to, at least in part, downregulation of AQP1 and AQP4 expression after TBI.
American Psychological Association (APA)
Chen, Gunng-Shinng& Huang, Kuo-Feng& Huang, Chien-Chu& Wang, Jia-Yi. 2015. Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056534
Modern Language Association (MLA)
Chen, Gunng-Shinng…[et al.]. Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056534
American Medical Association (AMA)
Chen, Gunng-Shinng& Huang, Kuo-Feng& Huang, Chien-Chu& Wang, Jia-Yi. Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056534