A Comparison of the Process of Remodeling of HydroxyapatitePoly-DL-Lactide and Beta-Tricalcium Phosphate in a Loading Site

Abstract EN

Currently, the most commonly used bioresorbable scaffold is made of beta-tricalcium phosphate (β-TCP); it is hoped that scaffolds made of a mixture of hydroxyapatite (HA) and poly-D/L-lactide (PDLLA) will be able to act as novel bioresorbable scaffolds.

The aim of this study was to evaluate the utility of a HA/PDLLA scaffold compared to β-TCP, at a loading site.

Dogs underwent surgery to replace a section of tibial bone with a bioresorbable scaffold.

After the follow-up period, the scaffold was subjected to histological analysis.

The HA/PDLLA scaffold showed similar bone formation and superior cell and tissue infiltration compared to the β-TCP scaffold, as seen after Villanueva Goldner staining.

Moreover, silver staining and immunohistochemistry for Von Willebrand factor and cathepsin K demonstrated better cell infiltration in the HA/PDLLA scaffold.

The fibrous tissue and cells that had infiltrated into the HA/PDLLA scaffold tested positive for collagen type I and RUNX2, respectively, indicating that the tissue and cells that had infiltrated into the HA/PDLLA scaffold had the potential to differentiate into bone.

The HA/PDLLA scaffold is therefore likely to find clinical application as a new bioresorbable scaffold.