Fibroblast Growth Factors Stimulate Hair Growth through β-Catenin and Shh Expression in C57BL6 Mice
Joint Authors
Xiao, Jian
Huang, Yan
Li, Xiao-kun
Lin, Wei-hong
Xiang, Li-Jun
Shi, Hong-Xue
Zhang, Jian
Jiang, Li-ping
Cai, Ping-tao
Lin, Zhen-Lang
Zhang, Hai-Lin
Fu, Xiao-Bing
Wang, Xiao-Jie
Guo, Ding-Jiong
Lin, Bei-Bei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Growth factors are involved in the regulation of hair morphogenesis and cycle hair growth.
The present study sought to investigate the hair growth promoting activities of three approved growth factor drugs, fibroblast growth factor 10 (FGF-10), acidic fibroblast growth factor (FGF-1), and basic fibroblast growth factor (FGF-2), and the mechanism of action.
We observed that FGFs promoted hair growth by inducing the anagen phase in telogenic C57BL/6 mice.
Specifically, the histomorphometric analysis data indicates that topical application of FGFs induced an earlier anagen phase and prolonged the mature anagen phase, in contrast to the control group.
Moreover, the immunohistochemical analysis reveals earlier induction of β-catenin and Sonic hedgehog (Shh) in hair follicles of the FGFs-treated group.
These results suggest that FGFs promote hair growth by inducing the anagen phase in resting hair follicles and might be a potential hair growth-promoting agent.
American Psychological Association (APA)
Lin, Wei-hong& Xiang, Li-Jun& Shi, Hong-Xue& Zhang, Jian& Jiang, Li-ping& Cai, Ping-tao…[et al.]. 2015. Fibroblast Growth Factors Stimulate Hair Growth through β-Catenin and Shh Expression in C57BL6 Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056536
Modern Language Association (MLA)
Lin, Wei-hong…[et al.]. Fibroblast Growth Factors Stimulate Hair Growth through β-Catenin and Shh Expression in C57BL6 Mice. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056536
American Medical Association (AMA)
Lin, Wei-hong& Xiang, Li-Jun& Shi, Hong-Xue& Zhang, Jian& Jiang, Li-ping& Cai, Ping-tao…[et al.]. Fibroblast Growth Factors Stimulate Hair Growth through β-Catenin and Shh Expression in C57BL6 Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056536