The TF-miRNA Coregulation Network in Oral Lichen Planus
Joint Authors
Zuo, Yu-Ling
Gong, Di-Ping
Li, Bi-Ze
Zhao, Juan
Zhou, Ling-Yue
Shao, Fang-Yang
Jin, Zhao
He, Yuan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oral lichen planus (OLP) is a chronic inflammatory disease that affects oral mucosa, some of which may finally develop into oral squamous cell carcinoma.
Therefore, pinpointing the molecular mechanisms underlying the pathogenesis of OLP is important to develop efficient treatments for OLP.
Recently, the accumulation of the large amount of omics data, especially transcriptome data, provides opportunities to investigate OLPs from a systematic perspective.
In this paper, assuming that the OLP associated genes have functional relationships, we present a new approach to identify OLP related gene modules from gene regulatory networks.
In particular, we find that the gene modules regulated by both transcription factors (TFs) and microRNAs (miRNAs) play important roles in the pathogenesis of OLP and many genes in the modules have been reported to be related to OLP in the literature.
American Psychological Association (APA)
Zuo, Yu-Ling& Gong, Di-Ping& Li, Bi-Ze& Zhao, Juan& Zhou, Ling-Yue& Shao, Fang-Yang…[et al.]. 2015. The TF-miRNA Coregulation Network in Oral Lichen Planus. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056543
Modern Language Association (MLA)
Zuo, Yu-Ling…[et al.]. The TF-miRNA Coregulation Network in Oral Lichen Planus. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056543
American Medical Association (AMA)
Zuo, Yu-Ling& Gong, Di-Ping& Li, Bi-Ze& Zhao, Juan& Zhou, Ling-Yue& Shao, Fang-Yang…[et al.]. The TF-miRNA Coregulation Network in Oral Lichen Planus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056543