Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery
Joint Authors
Islam, Md. Mirazul
Mohamed, Zahurin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The blood-brain barrier (BBB) is a dynamic and highly selective permeable interface between central nervous system (CNS) and periphery that regulates the brain homeostasis.
Increasing evidences of neurological disorders and restricted drug delivery process in brain make BBB as special target for further study.
At present, neurovascular unit (NVU) is a great interest and highlighted topic of pharmaceutical companies for CNS drug design and delivery approaches.
Some recent advancement of pharmacology and computational biology makes it convenient to develop drugs within limited time and affordable cost.
In this review, we briefly introduce current understanding of the NVU, including molecular and cellular composition, physiology, and regulatory function.
We also discuss the recent technology and interaction of pharmacogenomics and bioinformatics for drug design and step towards personalized medicine.
Additionally, we develop gene network due to understand NVU associated transporter proteins interactions that might be effective for understanding aetiology of neurological disorders and new target base protective therapies development and delivery.
American Psychological Association (APA)
Islam, Md. Mirazul& Mohamed, Zahurin. 2015. Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056544
Modern Language Association (MLA)
Islam, Md. Mirazul& Mohamed, Zahurin. Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056544
American Medical Association (AMA)
Islam, Md. Mirazul& Mohamed, Zahurin. Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056544