A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium
Joint Authors
Kharche, Sanjay R.
Biktasheva, Irina V.
Biktashev, Vadim N.
Zhang, Henggui
Seemann, Gunnar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The interaction of spiral waves of excitation with atrial anatomy remains unclear.
This simulation study isolates the role of atrial anatomical structures on spiral wave spontaneous drift in the human atrium.
We implemented realistic and idealised 3D human atria models to investigate the functional impact of anatomical structures on the long-term (∼40 s) behaviour of spiral waves.
The drift of a spiral wave was quantified by tracing its tip trajectory, which was correlated to atrial anatomical features.
The interaction of spiral waves with the following idealised geometries was investigated: (a) a wedge-like structure with a continuously varying atrial wall thickness; (b) a ridge-like structure with a sudden change in atrial wall thickness; (c) multiple bridge-like structures consisting of a bridge connected to the atrial wall.
Spiral waves drifted from thicker to thinner regions and along ridge-like structures.
Breakthrough patterns caused by pectinate muscles (PM) bridges were also observed, albeit infrequently.
Apparent anchoring close to PM-atrial wall junctions was observed.
These observations were similar in both the realistic and the idealised models.
We conclude that spatially altering atrial wall thickness is a significant cause of drift of spiral waves.
PM bridges cause breakthrough patterns and induce transient anchoring of spiral waves.
American Psychological Association (APA)
Kharche, Sanjay R.& Biktasheva, Irina V.& Seemann, Gunnar& Zhang, Henggui& Biktashev, Vadim N.. 2015. A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056545
Modern Language Association (MLA)
Kharche, Sanjay R.…[et al.]. A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1056545
American Medical Association (AMA)
Kharche, Sanjay R.& Biktasheva, Irina V.& Seemann, Gunnar& Zhang, Henggui& Biktashev, Vadim N.. A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056545