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Postnatal Administration of Allopregnanolone Modifies Glutamate Release but Not BDNF Content in Striatum Samples of Rats Prenatally Exposed to Ethanol
Joint Authors
Yunes, Roberto
Estrella, Cecilia R.
García, Sebastián
Lara, Hernán E.
Cabrera, Ricardo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ethanol consumption during pregnancy may induce profound changes in fetal CNS development.
We postulate that some of the effects of ethanol on striatal glutamatergic transmission and neurotrophin expression could be modulated by allopregnanolone, a neurosteroid modulator of GABA A receptor activity.
We describe the acute pharmacological effect of allopregnanolone (65 μg/kg, s.c.) administered to juvenile male rats (day 21 of age) on the corticostriatal glutamatergic pathway, in both control and prenatally ethanol-exposed rats (two ip injections of 2.9 g/kg in 24% v/v saline solution on gestational day 8).
Prenatal ethanol administration decreased the K+-induced release of glutamate regarding the control group.
Interestingly, this effect was reverted by allopregnanolone.
Regarding BDNF, allopregnanolone decreases the content of this neurotrophic factor in the striatum of control groups.
However, both ethanol alone and ethanol plus allopregnanolone treated animals did not show any change regarding control values.
We suggest that prenatal ethanol exposure may produce an alteration of GABA A receptors which blocks the GABA agonist-like effect of allopregnanolone on rapid glutamate release, thus disturbing normal neural transmission.
Furthermore, the reciprocal interactions found between GABAergic neurosteroids and BDNF could underlie mechanisms operating during the neuronal plasticity of fetal development.
American Psychological Association (APA)
Yunes, Roberto& Estrella, Cecilia R.& García, Sebastián& Lara, Hernán E.& Cabrera, Ricardo. 2015. Postnatal Administration of Allopregnanolone Modifies Glutamate Release but Not BDNF Content in Striatum Samples of Rats Prenatally Exposed to Ethanol. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056559
Modern Language Association (MLA)
Yunes, Roberto…[et al.]. Postnatal Administration of Allopregnanolone Modifies Glutamate Release but Not BDNF Content in Striatum Samples of Rats Prenatally Exposed to Ethanol. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056559
American Medical Association (AMA)
Yunes, Roberto& Estrella, Cecilia R.& García, Sebastián& Lara, Hernán E.& Cabrera, Ricardo. Postnatal Administration of Allopregnanolone Modifies Glutamate Release but Not BDNF Content in Striatum Samples of Rats Prenatally Exposed to Ethanol. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056559