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Andrographolide Suppresses Proliferation of Nasopharyngeal Carcinoma Cells via Attenuating NF- κ B Pathway
Joint Authors
Peng, Tao
Hu, Min
Wu, Ting-Ting
Zhang, Cen
Chen, Zhe
Huang, Shuo
Zhou, Xu-Hong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Andrographolide (Andro) has been reported to have anticancer activity in multiple types of cancer due to its capacity to inactivate NF-κB pathway.
Previous studies showed the therapeutic potential of targeting NF-κB pathway in nasopharyngeal carcinoma (NPC).
However, the anticancer activity of Andro in NPC has not been reported.
In this study, we defined the anticancer effects of Andro in NPC and elucidated its potential mechanisms of action.
Our results showed that Andro significantly inhibited the proliferation and invasion of NPC cells ( P < 0.05 , resp.).
These anticancer activities were associated with cell apoptosis, cell death and induction of cell cycle arrest, and the downregulation of NF-κB target genes.
This work provides evidence that NF-κB pathway is a potential therapeutic target and may also be indispensable in the Andro-mediated anticancer activities in nasopharyngeal carcinoma.
American Psychological Association (APA)
Peng, Tao& Hu, Min& Wu, Ting-Ting& Zhang, Cen& Chen, Zhe& Huang, Shuo…[et al.]. 2015. Andrographolide Suppresses Proliferation of Nasopharyngeal Carcinoma Cells via Attenuating NF- κ B Pathway. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056562
Modern Language Association (MLA)
Peng, Tao…[et al.]. Andrographolide Suppresses Proliferation of Nasopharyngeal Carcinoma Cells via Attenuating NF- κ B Pathway. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056562
American Medical Association (AMA)
Peng, Tao& Hu, Min& Wu, Ting-Ting& Zhang, Cen& Chen, Zhe& Huang, Shuo…[et al.]. Andrographolide Suppresses Proliferation of Nasopharyngeal Carcinoma Cells via Attenuating NF- κ B Pathway. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056562