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Discover the Molecular Biomarker Associated with Cell Death and Extracellular Matrix Module in Ovarian Cancer
Joint Authors
Liu, Qiang
Guo, Jianxin
Cui, Jinghong
Wang, Jing
Yi, Ping
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
High throughput technologies have provided many new research methods for ovarian cancer investigation.
In tradition, in order to find the underlying functional mechanisms of the survival-associated genes, gene sets enrichment analysis (GSEA) is always regarded as the important choice.
However, GSEA produces too many candidate genes and cannot discover the signaling transduction cascades.
In this work, we have used a network-based strategy to optimize the discovery of biomarkers using multifactorial data, including patient expression, clinical survival, and protein-protein interaction (PPI) data.
The biomarkers discovered by this strategy belong to the network-based biomarker, which is apt to reveal the underlying functional mechanisms of the biomarker.
In this work, over 400 expression arrays in ovarian cancer have been analyzed: the results showed that cell death and extracellular module are the main themes related to ovarian cancer progression.
American Psychological Association (APA)
Liu, Qiang& Guo, Jianxin& Cui, Jinghong& Wang, Jing& Yi, Ping. 2015. Discover the Molecular Biomarker Associated with Cell Death and Extracellular Matrix Module in Ovarian Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056566
Modern Language Association (MLA)
Liu, Qiang…[et al.]. Discover the Molecular Biomarker Associated with Cell Death and Extracellular Matrix Module in Ovarian Cancer. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056566
American Medical Association (AMA)
Liu, Qiang& Guo, Jianxin& Cui, Jinghong& Wang, Jing& Yi, Ping. Discover the Molecular Biomarker Associated with Cell Death and Extracellular Matrix Module in Ovarian Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056566