Role and Importance of IGF-1 in Traumatic Brain Injuries
Joint Authors
Mangiola, Annunziato
Vigo, Vera
Anile, Carmelo
De Bonis, Pasquale
Marziali, Giammaria
Lofrese, Giorgio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
It is increasingly affirmed that most of the long-term consequences of TBI are due to molecular and cellular changes occurring during the acute phase of the injury and which may, afterwards, persist or progress.
Understanding how to prevent secondary damage and improve outcome in trauma patients, has been always a target of scientific interest.
Plans of studies focused their attention on the posttraumatic neuroendocrine dysfunction in order to achieve a correlation between hormone blood level and TBI outcomes.
The somatotropic axis (GH and IGF-1) seems to be the most affected, with different alterations between the acute and late phases.
IGF-1 plays an important role in brain growth and development, and it is related to repair responses to damage for both the central and peripheral nervous system.
The IGF-1 blood levels result prone to decrease during both the early and late phases after TBI.
Despite this, experimental studies on animals have shown that the CNS responds to the injury upregulating the expression of IGF-1; thus it appears to be related to the secondary mechanisms of response to posttraumatic damage.
We review the mechanisms involving IGF-1 in TBI, analyzing how its expression and metabolism may affect prognosis and outcome in head trauma patients.
American Psychological Association (APA)
Mangiola, Annunziato& Vigo, Vera& Anile, Carmelo& De Bonis, Pasquale& Marziali, Giammaria& Lofrese, Giorgio. 2015. Role and Importance of IGF-1 in Traumatic Brain Injuries. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056567
Modern Language Association (MLA)
Mangiola, Annunziato…[et al.]. Role and Importance of IGF-1 in Traumatic Brain Injuries. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056567
American Medical Association (AMA)
Mangiola, Annunziato& Vigo, Vera& Anile, Carmelo& De Bonis, Pasquale& Marziali, Giammaria& Lofrese, Giorgio. Role and Importance of IGF-1 in Traumatic Brain Injuries. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056567