Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis
Joint Authors
Sue, Soichiro
Maeda, Shin
Shibata, Wataru
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Helicobacter pylori (H.
pylori) induces chronic gastric inflammation, atrophic gastritis, intestinal metaplasia, and cancer.
Although the risk of gastric cancer increases exponentially with the extent of atrophic gastritis, the precise mechanisms of gastric carcinogenesis have not been fully elucidated.
H.
pylori induces genetic and epigenetic changes in gastric epithelial cells through activating intracellular signaling pathways in a cagPAI-dependent manner.
H.
pylori eventually induces gastric cancer with chromosomal instability (CIN) or microsatellite instability (MSI), which are classified as two major subtypes of gastric cancer.
Elucidation of the precise mechanisms of gastric carcinogenesis will also be important for cancer therapy.
American Psychological Association (APA)
Sue, Soichiro& Shibata, Wataru& Maeda, Shin. 2015. Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056569
Modern Language Association (MLA)
Sue, Soichiro…[et al.]. Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056569
American Medical Association (AMA)
Sue, Soichiro& Shibata, Wataru& Maeda, Shin. Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056569