Fixation of Light Weight Polypropylene Mesh with n-Butyl-2-cyanocrylate in Pelvic Floor Surgery: Experimental Design Approach in Sheep for Effectiveness Evaluation
Joint Authors
García, Félix
Moll, Xavier
Barbosa, Sandra
Nieves, Tania
Cepeda, Eva
Marco, Alberto
Weis, Christine
Turon, Pau
Vergara, Patri
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The aim of this study was to find a proper experimental design and to evaluate n-butyl-2-cyanoacrylate (Histoacryl) as a fixation method for a light-weight and large pore PP mesh (Synthetic PP Mesh-1) using the sheep as an animal model.
Methods.
Posterior vaginal implantation by means of episiotomy was used to implant 8 ewes which were evaluated macroscopically and histologically at 3 months ( n = 4 ) and 6 months ( n = 4 ) post-surgery.
In previous pilot studies anterior vaginal implantation was evaluated, as well as different synthetic mesh materials, sizes and fixation methods ( n = 1 to 3) during three weeks.
In all cases a clinical evaluation of the animal was performed.
Results.
A reduction in the mesh size (Synthetic PP Mesh-1) together with precise application of the surgical glue Histoacryl to fix the mesh yielded significantly better histocompatibility results ( P < 0.01 ) compared to larger size or other fixation methods.
Conclusion.
The combination of Synthetic PP Mesh-1 with Histoacryl offered a high degree of graft integration without vaginal ulceration and a minimal foreign body reaction, being the sheep a proper animal model to test these types of medical devices.
American Psychological Association (APA)
Barbosa, Sandra& Nieves, Tania& García, Félix& Cepeda, Eva& Moll, Xavier& Marco, Alberto…[et al.]. 2015. Fixation of Light Weight Polypropylene Mesh with n-Butyl-2-cyanocrylate in Pelvic Floor Surgery: Experimental Design Approach in Sheep for Effectiveness Evaluation. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056570
Modern Language Association (MLA)
Barbosa, Sandra…[et al.]. Fixation of Light Weight Polypropylene Mesh with n-Butyl-2-cyanocrylate in Pelvic Floor Surgery: Experimental Design Approach in Sheep for Effectiveness Evaluation. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056570
American Medical Association (AMA)
Barbosa, Sandra& Nieves, Tania& García, Félix& Cepeda, Eva& Moll, Xavier& Marco, Alberto…[et al.]. Fixation of Light Weight Polypropylene Mesh with n-Butyl-2-cyanocrylate in Pelvic Floor Surgery: Experimental Design Approach in Sheep for Effectiveness Evaluation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056570