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The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil
Joint Authors
Sprinz, Eduardo
Lopes, Carmen Andréa F.
Falci, Diego R.
Soares, Marcelo A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
HIV related mutations can be associated with decreased susceptibility to antiretrovirals and treatment failures.
There is scarce information about HIV mutations in persons failing HIV treatment in North of Brazil.
Our aim was to evaluate evolution of HIV subtypes and mutations patterns related to antiretroviral therapy in this region.
We investigated HIV resistance profile in adults failing antiretroviral regimen in Northern Brazil from January, 2004, through December, 2013.
Genotype data was evaluated through Stanford University algorithm.
There were 377 genotypes from different individuals to evaluate.
Resistance mutations were similar to worldwide reports and related to antiretroviral exposure.
Most prevalent mutations in the reverse transcriptase gene were M184V (80.1%) and K130N (40.6%).
Thymidine associated mutations were more frequent in multiexperienced patients.
Most common protease mutations were M46I, V82A, I54V, L90M, I84V, M46L, and L76V.
Subtype B was the most prevalent (90.7%).
There were differences between subtypes B and non-B mutations.
We documented for the first time subtypes and patterns of HIV associated mutations in Northern Brazil.
A1 subtype was identified for the first time in this area.
Depending on drug regimen and how experienced the patient is, an empirical switch of a failing antiretroviral treatment could be a reasonable option.
American Psychological Association (APA)
Lopes, Carmen Andréa F.& Soares, Marcelo A.& Falci, Diego R.& Sprinz, Eduardo. 2015. The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056573
Modern Language Association (MLA)
Lopes, Carmen Andréa F.…[et al.]. The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056573
American Medical Association (AMA)
Lopes, Carmen Andréa F.& Soares, Marcelo A.& Falci, Diego R.& Sprinz, Eduardo. The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056573