Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension
Joint Authors
Eljaszewicz, Andrzej
Gackowska, Lidia
Litwin, Mieczyslaw
Trojanek, Joanna
Niemirska, Anna
Wierzbicka, Aldona
Michalkiewicz, Jacek
Kubiszewska, Izabela
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of the study was to find out whether peripheral blood leukocyte adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) protein expression patterns (flow cytometry) differ between the primary hypertension children (n=57) and healthy controls (n=19) and if their expression levels are related to selected clinical parameters.
The group of 26 patients [AdipoR(−)] showed lower and the group of 31 patients [AdipoR(+)] showed higher AdipoRs protein expression than the control and each other (P<0.01 for neutrophils, P<0.05 for monocytes).
The AdipoR(+) leukocytes expressed higher AdipoR1 mRNA levels (RT-PCR) than AdipoR(−) ones and controls (P=0.022 and P=0.007, resp.).
Despite greater BMI, the AdipoR(−) patients had unchanged serum adiponectin levels.
In contrast, AdipoR(+) patients had lower serum adiponectin concentrations than the AdipoR(−) ones and controls (P<0.001).
The AdipoR(+) patients had higher blood pressure (P=0.042) and greater carotid intima-media thickness (P=0.017) than the AdipoR(−) ones.
The stage of hypertension was associated with increased neutrophil but not monocyte AdipoR1 density (AdipoR1 MFI) (P<0.05).
Severe ambulatory hypertension was presented more often in AdipoR(+) patients than in AdipoR(−) ones (51.6% versus 26.9%, resp.; P<0.01).
In conclusion, neutrophil AdipoRs upregulation was associated with early stages of vascular injury, hypertension severity, and low serum levels of adiponectin.
American Psychological Association (APA)
Gackowska, Lidia& Litwin, Mieczyslaw& Trojanek, Joanna& Eljaszewicz, Andrzej& Kubiszewska, Izabela& Niemirska, Anna…[et al.]. 2015. Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056584
Modern Language Association (MLA)
Gackowska, Lidia…[et al.]. Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056584
American Medical Association (AMA)
Gackowska, Lidia& Litwin, Mieczyslaw& Trojanek, Joanna& Eljaszewicz, Andrzej& Kubiszewska, Izabela& Niemirska, Anna…[et al.]. Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056584