Clinicopathological and Immunological Changes in Indian Post Kala-Azar Dermal Leishmaniasis (PKDL) Cases in relation to Treatment: A Retrospective Study
Joint Authors
Sinha, Prabhat K.
Lal, Chandra Shekhar
Rabidas, Vidyanand
Pandey, Krishna
Singh, Dharmendra
Verma, Neena
Bimal, Sanjiv
Singh, Ashish Kumar
Das, Pradeep
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Post-kala-azar dermal leishmaniasis (PKDL) is an important factor in kala-azar transmission; hence its early detection and assessment of effective treatment is very important for disease control.
In present study on 60 PKDL cases presented with macular, mixed papulonodular, or erythematous lesions, Leishmania parasites were demonstrated microscopically in 91% of papulonodular and 40% of macular lesions.
Cellular infiltrates in skin biopsy imprint smears from lesions were mononuclear cells, 25–300/OIF (oil immersion field), predominantly histiocytes with vacuolation, many lymphocytes, some plasma cells, and Leishmania amastigotes 0–20/OIF.
Cases with no demonstrable parasites were diagnosed on the basis of past history of VL, lesion’s distribution, cytopathological changes, and positive DAT (86.83%).
Following antileishmanial treatment with SAG, papulonodular forms of PKDL lesions disappeared clinically but microscopically the mononuclear cells (20–200/OIF) persisted in the dermal lesions.
Response observed in macular PKDL lesions was poor which persisted both clinically and cytopathologically.
Follow-up of PKDL will assess the effectivity of treatment as either disappearance of lesions or any relapse.
Studies on involvement of immunological factors, that is, certain cytokines (IL-10, TGF-β, etc.) and chemokines (macrophage inflammatory protein, MIP 1- α , etc.) in PKDL, may provide insight for any role in the treatment response.
American Psychological Association (APA)
Verma, Neena& Bimal, Sanjiv& Rabidas, Vidyanand& Pandey, Krishna& Singh, Dharmendra& Lal, Chandra Shekhar…[et al.]. 2015. Clinicopathological and Immunological Changes in Indian Post Kala-Azar Dermal Leishmaniasis (PKDL) Cases in relation to Treatment: A Retrospective Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056591
Modern Language Association (MLA)
Verma, Neena…[et al.]. Clinicopathological and Immunological Changes in Indian Post Kala-Azar Dermal Leishmaniasis (PKDL) Cases in relation to Treatment: A Retrospective Study. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1056591
American Medical Association (AMA)
Verma, Neena& Bimal, Sanjiv& Rabidas, Vidyanand& Pandey, Krishna& Singh, Dharmendra& Lal, Chandra Shekhar…[et al.]. Clinicopathological and Immunological Changes in Indian Post Kala-Azar Dermal Leishmaniasis (PKDL) Cases in relation to Treatment: A Retrospective Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056591