Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy
Joint Authors
Puttachary, Sreekanth
Sharma, Shaunik
Stark, Sara
Thippeswamy, Thimmasettappa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-20
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
An insult to the brain (such as the first seizure) causes excitotoxicity, neuroinflammation, and production of reactive oxygen/nitrogen species (ROS/RNS).
ROS and RNS produced during status epilepticus (SE) overwhelm the mitochondrial natural antioxidant defense mechanism.
This leads to mitochondrial dysfunction and damage to the mitochondrial DNA.
This in turn affects synthesis of various enzyme complexes that are involved in electron transport chain.
Resultant effects that occur during epileptogenesis include lipid peroxidation, reactive gliosis, hippocampal neurodegeneration, reorganization of neural networks, and hypersynchronicity.
These factors predispose the brain to spontaneous recurrent seizures (SRS), which ultimately establish into temporal lobe epilepsy (TLE).
This review discusses some of these issues.
Though antiepileptic drugs (AEDs) are beneficial to control/suppress seizures, their long term usage has been shown to increase ROS/RNS in animal models and human patients.
In established TLE, ROS/RNS are shown to be harmful as they can increase the susceptibility to SRS.
Further, in this paper, we review briefly the data from animal models and human TLE patients on the adverse effects of antiepileptic medications and the plausible ameliorating effects of antioxidants as an adjunct therapy.
American Psychological Association (APA)
Puttachary, Sreekanth& Sharma, Shaunik& Stark, Sara& Thippeswamy, Thimmasettappa. 2015. Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy. BioMed Research International،Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1056593
Modern Language Association (MLA)
Puttachary, Sreekanth…[et al.]. Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy. BioMed Research International No. 2015 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1056593
American Medical Association (AMA)
Puttachary, Sreekanth& Sharma, Shaunik& Stark, Sara& Thippeswamy, Thimmasettappa. Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1056593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056593