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Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma
Joint Authors
Varshosaz, Jaleh
Rostami, M.
Haghjooy-Javanmard, Shaghayegh
Taymouri, Somayeh
Hassanzadeh, Farshid
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-08
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The objective of this study was the synthesis of folic acid- (FA-) targeted polymeric micelles of Synperonic PE/F 127-cholesteryl hemisuccinate (PF127-Chol) for specific delivery of docetaxel (DTX).
Targeted or nontargeted micelles loaded with DTX were prepared via dialysis method.
The effects of processing variables on the physicochemical properties of targeted micelles were evaluated using a full factorial design.
After the optimization of the polymer/drug ratio, the organic solvent type used for the preparation of the micelles, and the temperature of dialyzing medium, the in vitro cytotoxicity and cellular uptake of the optimized micelles were studied on B16F10 melanoma cells by flow cytometry and fluorescent microscopy.
The anticancer efficacy of DTX-loaded FA-PF127-Chol was evaluated in mice bearing melanoma tumor.
Optimized targeted micelles had the particle size of 171.3 nm, zeta potential of −7.8 mV, PDI of 0.325, and a high encapsulation efficiency that released the drug within 144 h.
The MTT assay indicated that targeted micelles carrying DTX were significantly more cytotoxic, had higher cellular uptake, and reduced the tumor volume significantly more than the nontargeted micelles and the free drug.
FA-PF127-Chol could be, therefore, a promising biomaterial for tumors overexpressing folate receptors.
American Psychological Association (APA)
Varshosaz, Jaleh& Taymouri, Somayeh& Hassanzadeh, Farshid& Haghjooy-Javanmard, Shaghayegh& Rostami, M.. 2015. Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056597
Modern Language Association (MLA)
Varshosaz, Jaleh…[et al.]. Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1056597
American Medical Association (AMA)
Varshosaz, Jaleh& Taymouri, Somayeh& Hassanzadeh, Farshid& Haghjooy-Javanmard, Shaghayegh& Rostami, M.. Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056597