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Cytokines and growth factors in Duchene muscular dystrophy patients
Joint Authors
Abd al-Salam, Ekram
Korraa, Suhayr
Abd al-Majid, Iman E.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 9, Issue 2 (30 Nov. 2008), pp.181-188, 8 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2008-11-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction : dystrophin deficiency associated with Duchene muscular dystrophy (DMD) results in chronic inflammation and severe skeletal muscle degeneration, where the extent of muscle.
Fibrosis contributes to disease severity the microenvironment of dystrophic muscles is associated with variation in levels of cytokine and growth factors.
Most of the current researches test for such cytokines and growth factors in tissue biopsies, which is an invasive Technique.
The Aim: Of the present study is to investigate whether cytokines and growth factors, as indicators of inflammatory response, can be detected in blood of DMD patients as non-invasive technique.
Patient and Methods : Accordingly the cytokine tumor necrosis factor alfa (TNF TNF-a), as well as the growth factors basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) were measured in blood of 24 boys with DMD diagnosed clinically and at the molecular level versus 20 age matching healthy boys Results : showed a significant increases in TNF-a (30.2 ± 9.5 vs.
3.6 ± 0.9 pg / ml) and bFGF (21.7 ± 10.3 vs.
4.75 ± 2.2 pg / ml.), while VEGF was significantly decreased (190 ± 115 vs.
210 ± 142 pg / ml) in blood of DMD patients compared to controls.
Conclusion : results provide further proof that inflammatory response is associated with DMD pathogenesis and favors the use of biomarkers in blood of such patients as a noninvasive technique.
American Psychological Association (APA)
Abd al-Majid, Iman E.& Abd al-Salam, Ekram& Korraa, Suhayr. 2008. Cytokines and growth factors in Duchene muscular dystrophy patients. The Egyptian Journal of Medical Human Genetics،Vol. 9, no. 2, pp.181-188.
https://search.emarefa.net/detail/BIM-105660
Modern Language Association (MLA)
Abd al-Majid, Iman E.…[et al.]. Cytokines and growth factors in Duchene muscular dystrophy patients. The Egyptian Journal of Medical Human Genetics Vol. 9, no. 2 (Nov. 2008), pp.181-188.
https://search.emarefa.net/detail/BIM-105660
American Medical Association (AMA)
Abd al-Majid, Iman E.& Abd al-Salam, Ekram& Korraa, Suhayr. Cytokines and growth factors in Duchene muscular dystrophy patients. The Egyptian Journal of Medical Human Genetics. 2008. Vol. 9, no. 2, pp.181-188.
https://search.emarefa.net/detail/BIM-105660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 185 -188
Record ID
BIM-105660