Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling
Joint Authors
Li, Lin
Hua, Lin
Li, Dongguo
Xia, Hong
Li, Zhen-ya
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Breast cancer is a heterogeneous disease with well-defined molecular subtypes.
Currently, comparative genomic hybridization arrays (aCGH) techniques have been developed rapidly, and recent evidences in studies of breast cancer suggest that tumors within gene expression subtypes share similar DNA copy number aberrations (CNA) which can be used to further subdivide subtypes.
Moreover, subtype-specific miRNA expression profiles are also proposed as novel signatures for breast cancer classification.
The identification of mRNA or miRNA expression-based breast cancer subtypes is considered an instructive means of prognosis.
Here, we conducted an integrated analysis based on copy number aberrations data and miRNA-mRNA dual expression profiling data to identify breast cancer subtype-specific biomarkers.
Interestingly, we found a group of genes residing in subtype-specific CNA regions that also display the corresponding changes in mRNAs levels and their target miRNAs’ expression.
Among them, the predicted direct correlation of BRCA1-miR-143-miR-145 pairs was selected for experimental validation.
The study results indicated that BRCA1 positively regulates miR-143-miR-145 expression and miR-143-miR-145 can serve as promising novel biomarkers for breast cancer subtyping.
In our integrated genomics analysis and experimental validation, a new frame to predict candidate biomarkers of breast cancer subtype is provided and offers assistance in order to understand the potential disease etiology of the breast cancer subtypes.
American Psychological Association (APA)
Li, Dongguo& Xia, Hong& Li, Zhen-ya& Hua, Lin& Li, Lin. 2015. Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056600
Modern Language Association (MLA)
Li, Dongguo…[et al.]. Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1056600
American Medical Association (AMA)
Li, Dongguo& Xia, Hong& Li, Zhen-ya& Hua, Lin& Li, Lin. Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056600