RhoGTPases as Key Players in Mammalian Cell Adaptation to Microgravity
Joint Authors
Louis, Fiona
Deroanne, Christophe
Nusgens, Betty
Vico, Laurence
Guignandon, Alain
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
A growing number of studies are revealing that cells reorganize their cytoskeleton when exposed to conditions of microgravity.
Most, if not all, of the structural changes observed on flown cells can be explained by modulation of RhoGTPases, which are mechanosensitive switches responsible for cytoskeletal dynamics control.
This review identifies general principles defining cell sensitivity to gravitational stresses.
We discuss what is known about changes in cell shape, nucleus, and focal adhesions and try to establish the relationship with specific RhoGTPase activities.
We conclude by considering the potential relevance of live imaging of RhoGTPase activity or cytoskeletal structures in order to enhance our understanding of cell adaptation to microgravity-related conditions.
American Psychological Association (APA)
Louis, Fiona& Deroanne, Christophe& Nusgens, Betty& Vico, Laurence& Guignandon, Alain. 2015. RhoGTPases as Key Players in Mammalian Cell Adaptation to Microgravity. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056605
Modern Language Association (MLA)
Louis, Fiona…[et al.]. RhoGTPases as Key Players in Mammalian Cell Adaptation to Microgravity. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1056605
American Medical Association (AMA)
Louis, Fiona& Deroanne, Christophe& Nusgens, Betty& Vico, Laurence& Guignandon, Alain. RhoGTPases as Key Players in Mammalian Cell Adaptation to Microgravity. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056605