Role of Ketamine in Acute Postoperative Pain Management: A Narrative Review
Joint Authors
Sifonios, Anthony N.
Radvansky, Brian M.
Shah, Khushbu
Parikh, Anant
Le, Vanny
Eloy, Jean Daniel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
The objective of this narrative review was to examine the usage of ketamine as a postoperative analgesic agent across a wide variety of surgeries.
Design.
A literature search was performed using the phrases “ketamine” and “postoperative pain.” The authors analyzed the studies that involved testing ketamine’s effectiveness at controlling postoperative pain.
Effectiveness was assessed through various outcomes such as the amount of opiate consumption, visual analog scale (VAS) pain scores, and persistent postoperative pain at long-term follow-up.
Results.
While many different administration protocols were evaluated, delivering ketamine both as a pre- or perioperative bolus and postoperative infusion for up to 48 hours appeared to be the most effective.
These effects are dose-dependent.
However, a number of studies analyzed showed no benefit in using ketamine versus placebo for controlling postoperative pain.
While ketamine is a safe and well-tolerated drug, it does have adverse effects, and there are concerns for possible neurotoxicity and effects on memory.
Conclusions.
In a number of limited situations, ketamine has shown some efficacy in controlling postoperative pain and decreasing opioid consumption.
More randomized controlled trials are necessary to determine the surgical procedures and administrations (i.e., intravenous, epidural) that ketamine is best suited for.
American Psychological Association (APA)
Radvansky, Brian M.& Shah, Khushbu& Parikh, Anant& Sifonios, Anthony N.& Le, Vanny& Eloy, Jean Daniel. 2015. Role of Ketamine in Acute Postoperative Pain Management: A Narrative Review. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056615
Modern Language Association (MLA)
Radvansky, Brian M.…[et al.]. Role of Ketamine in Acute Postoperative Pain Management: A Narrative Review. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056615
American Medical Association (AMA)
Radvansky, Brian M.& Shah, Khushbu& Parikh, Anant& Sifonios, Anthony N.& Le, Vanny& Eloy, Jean Daniel. Role of Ketamine in Acute Postoperative Pain Management: A Narrative Review. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056615