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Cocaine Causes Apoptotic Death in Rat Mesencephalon and Striatum Primary Cultures
Joint Authors
Lepsch, Lucilia B.
Planeta, Cleopatra S.
Scavone, Critoforo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To study cocaine’s toxic effects in vitro, we have used primary mesencephalic and striatal cultures from rat embryonic brain.
Treatment with cocaine causes a dramatic increase in DNA fragmentation in both primary cultures.
The toxicity induced by cocaine was paralleled with a concomitant decrease in the microtubule associated protein 2 (MAP2) and/or neuronal nucleus protein (NeuN) staining.
We also observed in both cultures that the cell death caused by cocaine was induced by an apoptotic mechanism, confirmed by TUNEL assay.
Therefore, the present paper shows that cocaine causes apoptotic cell death and inhibition of the neurite prolongation in striatal and mesencephalic cell culture.
These data suggest that if similar neuronal damage could be produced in the developing human brain, it could account for the qualitative or quantitative defects in neuronal pathways that cause a major handicap in brain function following prenatal exposure to cocaine.
American Psychological Association (APA)
Lepsch, Lucilia B.& Planeta, Cleopatra S.& Scavone, Critoforo. 2015. Cocaine Causes Apoptotic Death in Rat Mesencephalon and Striatum Primary Cultures. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056618
Modern Language Association (MLA)
Lepsch, Lucilia B.…[et al.]. Cocaine Causes Apoptotic Death in Rat Mesencephalon and Striatum Primary Cultures. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056618
American Medical Association (AMA)
Lepsch, Lucilia B.& Planeta, Cleopatra S.& Scavone, Critoforo. Cocaine Causes Apoptotic Death in Rat Mesencephalon and Striatum Primary Cultures. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056618