Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats
Joint Authors
Hirata, Masataka
Ousaka, Daiki
Arai, Sadahiko
Okuyama, Michihiro
Tarui, Suguru
Kobayashi, Junko
Kasahara, Shingo
Sano, Shunji
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Congenital heart diseases often involve chronic pressure overload of the right ventricle (RV) which is a major cause of RV dysfunction.
Pulmonary artery (PA) banding has been used to produce animal models of RV dysfunction.
We have devised a new and easier method of constricting the PA and compared it directly with the partial ligation method.
Methods.
Eight-week-old male Sprague-Dawley rats (240–260 g) were divided into three groups: sham operation, partial pulmonary artery ligation (PAL) procedure, and pulmonary artery half-closed clip (PAC) procedure.
RV function and remodeling were determined by echocardiography and histomorphometry.
Results.
Surgical mortality was significantly lower in the PAC group while echocardiography revealed significantly more signs of RV dysfunction.
At the 8th week after surgery RV fibrosis rate was significantly higher in the PAC group.
Conclusions.
This procedure of pulmonary artery banding in rats is easier and more efficient than partial ligation.
American Psychological Association (APA)
Hirata, Masataka& Ousaka, Daiki& Tarui, Suguru& Kobayashi, Junko& Kasahara, Shingo& Sano, Shunji…[et al.]. 2015. Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056632
Modern Language Association (MLA)
Tarui, Suguru…[et al.]. Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056632
American Medical Association (AMA)
Hirata, Masataka& Ousaka, Daiki& Tarui, Suguru& Kobayashi, Junko& Kasahara, Shingo& Sano, Shunji…[et al.]. Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056632