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Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis
Joint Authors
Cassola, Giovanni
Cenderello, Giovanni
Revelli, Matteo
Rutigliani, Mariangela
Zefiro, Daniele
Cevasco, Luca
Amico, Maria
Bandelloni, Roberto
Rollandi, Gian Andrea
Forni, Gianluca
Paparo, Francesco
Bacigalupo, Lorenzo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To assess the diagnostic performance of a T1-independent, T2*-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of hepatic steatosis in a cohort of patients affected by chronic viral C hepatitis, using liver biopsy as gold standard.
Methods.
Eighty-one untreated patients with chronic viral C hepatitis were prospectively enrolled.
All included patients underwent MRI, transient elastography, and liver biopsy within a time interval <10 days.
Results.
Our cohort of 77 patients included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31 ± 11.27 (18–81) years.
The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r=0.754, 95% CI 0.637 to 0.836, P<0.0001), and the correlation was influenced by neither the liver stiffness nor the T2* decay.
The median MRI PDFF result was significantly lower in the F4 subgroup (P<0.05).
The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) for S≥1 and 0.929 (95% CI 0.847 to 0.975) for S=2.
Conclusions.
Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis.
American Psychological Association (APA)
Paparo, Francesco& Cenderello, Giovanni& Revelli, Matteo& Bacigalupo, Lorenzo& Rutigliani, Mariangela& Zefiro, Daniele…[et al.]. 2015. Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056646
Modern Language Association (MLA)
Paparo, Francesco…[et al.]. Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056646
American Medical Association (AMA)
Paparo, Francesco& Cenderello, Giovanni& Revelli, Matteo& Bacigalupo, Lorenzo& Rutigliani, Mariangela& Zefiro, Daniele…[et al.]. Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056646