Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension
Joint Authors
Li, Mengtao
Zeng, Xiaofeng
Zhou, Shuang
Jia, Yu-Yan
Liu, Jin-Jing
Wang, Qian
Tian, Zhuang
Liu, Yong-Tai
Chen, Hou-Zao
Liu, De-Pei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality in rheumatic diseases.
Vascular remodeling due to the proliferation of pulmonary arterial smooth muscle cells (PASMCs) is central to the development of PAH.
To date, it is still unclear if Silence Information Regulator 1 (SIRT1) regulates cell cycle regulators in the proliferation of PASMCs and contributes to prevention of PAH by resveratrol.
In this study, we found that a significant decrease of SIRT1 expression levels in platelet-derived growth factor BB (PDGF-BB) treated human PASMCs (HPASMCs) and in monocrotaline (MCT) induced PAH rat.
Overexpression of SIRT1 induced G1 phase arrest and increased p21 expression but decreased cyclin D1 expression in PDGF-BB treated HPASMCs.
Moreover, resveratrol attenuated pulmonary arterial remodeling, decreased pulmonary arterial pressure, and upregulated SIRT1 and p21 expression but downregulated cyclin D1 expression in MCT induced PAH rat.
Notably, knockdown of SIRT1 eliminated the regulation of resveratrol on p21 and cyclin D1 expression in PDGF-BB treated HPASMCs.
These results demonstrated that SIRT1 mediated the regulation of resveratrol on the expression of cell cycle regulatory molecules.
It suggests that SIRT1 exerts a protective role in PAH associated with rheumatic diseases and can be a potential treatment target.
American Psychological Association (APA)
Jia, Yu-Yan& Liu, Jin-Jing& Wang, Qian& Tian, Zhuang& Liu, Yong-Tai& Chen, Hou-Zao…[et al.]. 2015. Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056666
Modern Language Association (MLA)
Jia, Yu-Yan…[et al.]. Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1056666
American Medical Association (AMA)
Jia, Yu-Yan& Liu, Jin-Jing& Wang, Qian& Tian, Zhuang& Liu, Yong-Tai& Chen, Hou-Zao…[et al.]. Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056666