The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell Lung Cancer: A Meta-Analysis of Published Data
Joint Authors
Wang, Yang
Gao, Wen
Xu, Jiali
Chen, Xiaojun
Yang, Yang
Zhu, Yizhi
Yin, Yongmei
Guo, Renhua
Liu, Ping
Shu, Yongqian
Liu, Lingxiang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
The prognostic factors of the fibroblast growth factor receptor 1 (FGFR1) in non-small cell lung cancer (NSCLC) remain controversial.
Methods.
We conducted a meta-analysis of published studies from 1974 to February 2015.
In absence of quality difference between studies of reporting significant and nonsignificant results, the relationship between FGFR1 amplification and clinicopathological parameters in NSCLC was analyzed.
And also the combined hazard ratio (HR) and their corresponding 95% confidence interval (CI) were calculated in terms of overall survival.
Results.
3178 patients (12 studies) were included in the analysis.
It was shown that FGFR1 amplification was significantly more prevalent among male patients (RR 2.03, 95% CI 1.57–2.63) with squamous cell lung cancer (SQCC) (RR 3.49, 95% CI 2.62–4.64) and current smokers (RR 2.63, 95% CI 1.92–3.60).
The pooled data also showed that the FGFR1 amplification was a poor prognostic factor in SQCC (HR 1.38, 95% CI 1.07–1.78), Asian patients (HR 1.78, 95% CI 1.22–2.60), and fluorescence in situ hybridization (FISH) method (HR 1.30, 95% CI 1.06–1.58).
Conclusions.
This meta-analysis strongly suggests that FGFR1 amplification occurs more frequently in male, SQCC and smokers, and it is a risk factor for poor prognosis among Asian patients with SQCC.
American Psychological Association (APA)
Wang, Yang& Gao, Wen& Xu, Jiali& Chen, Xiaojun& Yang, Yang& Zhu, Yizhi…[et al.]. 2015. The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell Lung Cancer: A Meta-Analysis of Published Data. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056671
Modern Language Association (MLA)
Wang, Yang…[et al.]. The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell Lung Cancer: A Meta-Analysis of Published Data. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056671
American Medical Association (AMA)
Wang, Yang& Gao, Wen& Xu, Jiali& Chen, Xiaojun& Yang, Yang& Zhu, Yizhi…[et al.]. The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell Lung Cancer: A Meta-Analysis of Published Data. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056671