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Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade
Joint Authors
Deuse, Tobias
Guihaire, Julien
Wang, Dong
Fadel, Elie
Reichenspurner, Hermann
Schrepfer, Sonja
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The epidemiology of pulmonary hypertension (PH) is characterized by a female preponderance, whereas males share higher severity of the disease.
Objective.
To compare the severity of experimental PH between male and female athymic rats.
Methods.
PH was induced in 11 male and 11 female athymic rats (resp., SU_M and SU_F groups) using an inhibitor of VEGF-receptors I and II, semaxanib (40 mg/kg).
After 28 days, right ventricular (RV) remodeling, systolic function, and hemodynamics were measured using echocardiography and a pressure-volume admittance catheter.
Morphometric analyses of lung vasculature and RV myocardium were performed.
Results.
Four weeks after semaxanib injection, RV end-systolic pressure was higher in SU_M than in SU_F.
Males developed marked RV enlargement and systolic dysfunction compared to females.
Impairment of RV-PA coupling efficiency was observed only in SU_M.
The smooth muscle cells of the pulmonary arteries switched from a contractile state to a dedifferentiated state only in males.
Conclusions.
Female athymic rats were protected against the development of severe PH.
RV-PA coupling was preserved in females through limitation of pulmonary artery muscularization.
Control of smooth muscle cells plasticity may be a promising therapeutic approach to reverse established vascular remodeling in PH patients.
American Psychological Association (APA)
Guihaire, Julien& Deuse, Tobias& Wang, Dong& Fadel, Elie& Reichenspurner, Hermann& Schrepfer, Sonja. 2015. Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056678
Modern Language Association (MLA)
Guihaire, Julien…[et al.]. Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056678
American Medical Association (AMA)
Guihaire, Julien& Deuse, Tobias& Wang, Dong& Fadel, Elie& Reichenspurner, Hermann& Schrepfer, Sonja. Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056678