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Comparison between the Traditional and a Rapid Screening Test for Cryoimmunoglobulins Detection
Joint Authors
Di Stasio, Enrico
Romitelli, Federica
Pucillo, Leopoldo Paolo
Basile, Umberto
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
A new rapid, automatic, and sensitive screening test useful to detect cryoglobulins in serum samples is proposed.
Design and Methods.
The increase of turbidity during the cryoglobulin aggregation was monitored spectrophotometrically in sera from 400 patients with clinical evidence of cryoglobulinemia related disorders and 100 controls.
Results were correlated to those obtained by the traditional method.
Results.
Kinetics of the aggregation curves were described by their maximum turbidity increase, lag time, and slope.
Despite a partial correspondence between the traditional and the rapid test, patients with symptomatic cryoglobulinemia showed turbidity values significantly higher than the determined cutoff.
Moreover, a functional classification of cryoglobulins is proposed.
Conclusions.
Due to its high reproducibility, operator independence, low cost, and results obtained within 2 hours, the rapid test can be used as a “real time” monitoring of cryoglobulinemia related diseases and for the evaluation of plasmapheresis efficacy.
American Psychological Association (APA)
Romitelli, Federica& Pucillo, Leopoldo Paolo& Basile, Umberto& Di Stasio, Enrico. 2015. Comparison between the Traditional and a Rapid Screening Test for Cryoimmunoglobulins Detection. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056705
Modern Language Association (MLA)
Romitelli, Federica…[et al.]. Comparison between the Traditional and a Rapid Screening Test for Cryoimmunoglobulins Detection. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056705
American Medical Association (AMA)
Romitelli, Federica& Pucillo, Leopoldo Paolo& Basile, Umberto& Di Stasio, Enrico. Comparison between the Traditional and a Rapid Screening Test for Cryoimmunoglobulins Detection. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056705