Alpha-Mangostin Attenuation of Hyperglycemia-Induced Ocular Hypoperfusion and Blood Retinal Barrier Leakage in the Early Stage of Type 2 Diabetes Rats
Joint Authors
Jariyapongskul, Amporn
Areebambud, Chonticha
Suksamrarn, Sunit
Mekseepralard, Chantana
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study examined effects of alpha-mangostin (α-MG) supplementation on the retinal microvasculature, including ocular blood flow (OBF) and blood-retinal barrier (BRB) permeability in a type 2 diabetic animal model.
Male Sprague-Dawley rats were divided into four groups: normal control and diabetes with or without α-MG supplementation.
Alpha-mangostin (200 mg/Kg/day) was administered by gavage feeding for 8 weeks.
The effects of α-MG on biochemical and physiological parameters including mean arterial pressure (MAP), OBF, and BRB leakage were investigated.
Additionally, levels of retinal malondialdehyde (MDA), advance glycation end products (AGEs), receptor of advance glycation end products (RAGE), tumour necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF) were evaluated.
The elevated blood glucose, HbA1c, cholesterol, triglyceride, serum insulin, and HOMA-IR were observed in DM2 rats.
Moreover, DM2 rats had significantly decreased OBF but statistically increased MAP and leakage of the BRB.
The α-MG-treated DM2 rats showed significantly lower levels of retinal MDA, AGEs, RAGE, TNF-α, and VEGF than the untreated group.
Interestingly, α-MG supplementation significantly increased OBF while it decreased MAP and leakage of BRB.
In conclusion, α-MG supplementation could restore OBF and improve the BRB integrity, indicating its properties closely associated with antihyperglycemic, antioxidant, anti-inflammatory, and antiglycation activities.
American Psychological Association (APA)
Jariyapongskul, Amporn& Areebambud, Chonticha& Suksamrarn, Sunit& Mekseepralard, Chantana. 2015. Alpha-Mangostin Attenuation of Hyperglycemia-Induced Ocular Hypoperfusion and Blood Retinal Barrier Leakage in the Early Stage of Type 2 Diabetes Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056717
Modern Language Association (MLA)
Jariyapongskul, Amporn…[et al.]. Alpha-Mangostin Attenuation of Hyperglycemia-Induced Ocular Hypoperfusion and Blood Retinal Barrier Leakage in the Early Stage of Type 2 Diabetes Rats. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056717
American Medical Association (AMA)
Jariyapongskul, Amporn& Areebambud, Chonticha& Suksamrarn, Sunit& Mekseepralard, Chantana. Alpha-Mangostin Attenuation of Hyperglycemia-Induced Ocular Hypoperfusion and Blood Retinal Barrier Leakage in the Early Stage of Type 2 Diabetes Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056717