Ciclamilast Ameliorates Adjuvant-Induced Arthritis in a Rat Model
Joint Authors
Xie, Qiang-Min
Zhang, Zhi-cheng
Zhang, Shui-juan
Jin, Bo
Wu, Yujin
Yang, Xin-fu
Yu, Bing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We assessed the effect of a novel and selective phosphodiesterase 4 (PDE4) inhibitor, ciclamilast, on chronic inflammation in adjuvant-induced arthritis (AIA), a rat model of rheumatoid arthritis (RA), and acute inflammation in the rat and mouse model of carrageenan-induced paw edema and peritonitis.
Our results showed that daily oral administration of ciclamilast at 1, 3, and 10 mg/kg dose-dependently inhibited the increase in hind paw volume of rats with AIA.
The inhibition of paw edema was associated with inhibition of both the production of cytokines such as TNF-α, IL-1β, and IL-6 and cell infiltration assessed in subcutaneous paw tissue.
Moreover, there was significantly less tissue destruction in the ciclamilast-treated rats compared to the vehicle-treated rats, as assessed by radiographic analysis and histopathological evaluation.
In the two acute inflammation models, ciclamilast inhibited carrageenan-induced paw edema in rats and inflammatory cell migration into the peritoneal cavity in mice in a dose-dependent manner.
These results not only suggest that ciclamilast, as a disease-modifying antirheumatic drug (DMARD), can attenuate RA but also provide proof of principle that a PDE4 inhibitor may be useful for the treatment of arthritis.
American Psychological Association (APA)
Zhang, Zhi-cheng& Zhang, Shui-juan& Jin, Bo& Wu, Yujin& Yang, Xin-fu& Yu, Bing…[et al.]. 2015. Ciclamilast Ameliorates Adjuvant-Induced Arthritis in a Rat Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056718
Modern Language Association (MLA)
Zhang, Zhi-cheng…[et al.]. Ciclamilast Ameliorates Adjuvant-Induced Arthritis in a Rat Model. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056718
American Medical Association (AMA)
Zhang, Zhi-cheng& Zhang, Shui-juan& Jin, Bo& Wu, Yujin& Yang, Xin-fu& Yu, Bing…[et al.]. Ciclamilast Ameliorates Adjuvant-Induced Arthritis in a Rat Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056718