Prognostic Implications of Serum Lipid Metabolism over Time during Sepsis
Joint Authors
Lee, Sang Hoon
Park, Moo Suk
Park, Byung Hoon
Jung, Won Jai
Lee, In Seon
Kim, Song Yee
Kim, Eun Young
Jung, Ji Ye
Kang, Young Ae
Kim, Young Sam
Kim, Se Kyu
Chang, Joon
Chung, Kyung Soo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Despite extensive research and an improved standard of care, sepsis remains a disorder with a high mortality rate.
Sepsis is accompanied by severe metabolic alterations.
Methods.
We evaluated 117 patients with sepsis (severe sepsis [n=19] and septic shock [n=98]) who were admitted to the intensive care unit.
Serum cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), free fatty acid (FFA), and apolipoprotein (Apo) A-I levels were measured on days 0, 1, 3, and 7.
Results.
Nonsurvivors had low levels of cholesterol, TG, HDL, LDL, and Apo A-I on days 0, 1, 3, and 7.
In a linear mixed model analysis, the variations in TG, LDL, FFA, and Apo A-I levels over time differed significantly between the groups (p=0.043, p=0.020, p=0.005, and p=0.015, resp.).
According to multivariate analysis, TG levels and SOFA scores were associated with mortality on days 0 and 1 (p=0.018 and p=0.008, resp.).
Conclusions.
Our study illustrated that TG levels are associated with mortality in patients with sepsis.
This may be attributable to alterations in serum lipid metabolism during sepsis, thus modulating the host response to inflammation in critically ill patients.
American Psychological Association (APA)
Lee, Sang Hoon& Park, Moo Suk& Park, Byung Hoon& Jung, Won Jai& Lee, In Seon& Kim, Song Yee…[et al.]. 2015. Prognostic Implications of Serum Lipid Metabolism over Time during Sepsis. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056725
Modern Language Association (MLA)
Lee, Sang Hoon…[et al.]. Prognostic Implications of Serum Lipid Metabolism over Time during Sepsis. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056725
American Medical Association (AMA)
Lee, Sang Hoon& Park, Moo Suk& Park, Byung Hoon& Jung, Won Jai& Lee, In Seon& Kim, Song Yee…[et al.]. Prognostic Implications of Serum Lipid Metabolism over Time during Sepsis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056725