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Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy
Joint Authors
Suzuki, Hidekazu
Nishizawa, Toshihiro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The oxygen-derived free radicals that are released from activated neutrophils are one of the cytotoxic factors of Helicobacter pylori-induced gastric mucosal injury.
Increased cytidine deaminase activity in H.
pylori-infected gastric tissues promotes the accumulation of various mutations and might promote gastric carcinogenesis.
Cytotoxin-associated gene A (CagA) is delivered into gastric epithelial cells via bacterial type IV secretion system, and it causes inflammation and activation of oncogenic pathways.
H.
pylori infection induces epigenetic transformations, such as aberrant promoter methylation in tumor-suppressor genes.
Aberrant expression of microRNAs is also reportedly linked to gastric tumorogenesis.
Moreover, recent advances in molecular targeting therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2 (HER-2) therapies.
This updated review article highlights possible mechanisms of gastric carcinogenesis including H.
pylori-associated factors.
American Psychological Association (APA)
Nishizawa, Toshihiro& Suzuki, Hidekazu. 2015. Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056751
Modern Language Association (MLA)
Nishizawa, Toshihiro& Suzuki, Hidekazu. Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056751
American Medical Association (AMA)
Nishizawa, Toshihiro& Suzuki, Hidekazu. Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056751