The Genetic and Environmental Factors for Keratoconus
Joint Authors
Liu, Yutao
Gordon-Shaag, Ariela
Millodot, Michel
Shneor, Einat
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Keratoconus (KC) is the most common cornea ectatic disorder.
It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment.
It affects all ethnic groups and both genders.
Both environmental and genetic factors may contribute to its pathogenesis.
This review is to summarize the current research development in KC epidemiology and genetic etiology.
Environmental factors include but are not limited to eye rubbing, atopy, sun exposure, and geography.
Genetic discoveries have been reviewed with evidence from family-based linkage analysis and fine mapping in linkage region, genome-wide association studies, and candidate genes analyses.
A number of genes have been discovered at a relatively rapid pace.
The detailed molecular mechanism underlying KC pathogenesis will significantly advance our understanding of KC and promote the development of potential therapies.
American Psychological Association (APA)
Gordon-Shaag, Ariela& Millodot, Michel& Shneor, Einat& Liu, Yutao. 2015. The Genetic and Environmental Factors for Keratoconus. BioMed Research International،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1056757
Modern Language Association (MLA)
Gordon-Shaag, Ariela…[et al.]. The Genetic and Environmental Factors for Keratoconus. BioMed Research International No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1056757
American Medical Association (AMA)
Gordon-Shaag, Ariela& Millodot, Michel& Shneor, Einat& Liu, Yutao. The Genetic and Environmental Factors for Keratoconus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1056757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056757