Synthesis and Properties of Flexible Polyurethane Using Ferric Catalyst for Hypopharyngeal Tissue Engineering
Joint Authors
Zhu, Yabin
Shen, Zhisen
Wang, Jian
Lu, Dakai
Li, Qun
Zhou, Chongchang
Hu, Xiao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Biodegradable polyurethane is an ideal candidate material to fabricate tissue engineered hypopharynx from its good mechanical properties and biodegradability.
We thus synthesized a hydrophilic polyurethane via reactions among polyethylene glycol (PEG), e-caprolactone (e-CL) and hexamethylene diisocyanate (HDI), and thrihydroxymethyl propane (TMP).
The product possessed a fast degradability due to its good wettability and good mechanical parameters with the elongations at break (137 ± 10%) and tensile strength (4.73 ± 0.46 MPa), which will make it a good matrix material for soft tissue like hypopharynx.
Its biological properties were evaluated via in vitro and in vivo tests.
The results showed that this hydrophilic polyurethane material can support hypopharyngeal fibroblast growth and owned good degradability and low inflammatory reaction in subcutaneous implantation.
It will be proposed as the scaffold for hypopharyngeal tissue engineering research in our future study.
American Psychological Association (APA)
Shen, Zhisen& Wang, Jian& Lu, Dakai& Li, Qun& Zhou, Chongchang& Zhu, Yabin…[et al.]. 2015. Synthesis and Properties of Flexible Polyurethane Using Ferric Catalyst for Hypopharyngeal Tissue Engineering. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056770
Modern Language Association (MLA)
Shen, Zhisen…[et al.]. Synthesis and Properties of Flexible Polyurethane Using Ferric Catalyst for Hypopharyngeal Tissue Engineering. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056770
American Medical Association (AMA)
Shen, Zhisen& Wang, Jian& Lu, Dakai& Li, Qun& Zhou, Chongchang& Zhu, Yabin…[et al.]. Synthesis and Properties of Flexible Polyurethane Using Ferric Catalyst for Hypopharyngeal Tissue Engineering. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056770