Ultrastructural Morphology of Sperm from Human Globozoospermia
Joint Authors
Martinelli, Monica
Ricci, Giuseppe
Andolfi, Laura
Zabucchi, Giuliano
Boscolo, Rita
Zweyer, Marina
Trevisan, Elisa
Luppi, Stefania
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Globozoospermia is a rare disorder characterized by the presence of sperm with round head, lacking acrosome.
Coiling tail around the nucleus has been reported since early human studies, but no specific significance has conferred it.
By contrast, studies on animal models suggest that coiling tail around the nucleus could represent a crucial step of defective spermatogenesis, resulting in round-headed sperm.
No observations, so far, support the transfer of this hypothesis to human globozoospermia.
The purpose of this work was to compare ultrastructural morphology of human and mouse model globozoospermic sperm.
Sperm have been investigated by using scanning and transmission electron microscopy.
The images that we obtained show significant similarities to those described in GOPC knockout mice, an animal model of globozoospermia.
By using this model as reference, we were able to identify the probable steps of the tail coiling process in human globozoospermia.
Although we have no evidence that there is the same pathophysiology in man and knocked-out mouse, the similarities between these ultrastructural observations in human and those in the experimental model are very suggestive.
This is the first demonstration of the existence of relevant morphological homologies between the tail coiling in animal model and human globozoospermia.
American Psychological Association (APA)
Ricci, Giuseppe& Andolfi, Laura& Zabucchi, Giuliano& Luppi, Stefania& Boscolo, Rita& Martinelli, Monica…[et al.]. 2015. Ultrastructural Morphology of Sperm from Human Globozoospermia. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056772
Modern Language Association (MLA)
Ricci, Giuseppe…[et al.]. Ultrastructural Morphology of Sperm from Human Globozoospermia. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056772
American Medical Association (AMA)
Ricci, Giuseppe& Andolfi, Laura& Zabucchi, Giuliano& Luppi, Stefania& Boscolo, Rita& Martinelli, Monica…[et al.]. Ultrastructural Morphology of Sperm from Human Globozoospermia. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056772