Epidemiological and Molecular Characteristics of the PB1-F2 Proteins in H7N9 Influenza Viruses, Jiangsu
Joint Authors
Wei, Pingmin
Li, Wei
Zi, Hairong
Cunningham, Michael
Guo, Yan
Xuan, Yang
Musa, Taha Hussein
Luo, Pengfei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The recent sporadic infections of humans in China with previously unrecognized avian influenza A virus of the H7N9 subtype (A(H7N9)) have caused concern.
The aim is to find out the epidemiological and molecular analysis of the PB1-F2 proteins in H7N9 influenza viruses, in Jiangsu province.
Sequences were obtained from GISAID database.
Data were analyzed by using Molecular Evolutionary Genetics Analysis software and Bayesian Markov chain Monte Carlo method.
From March 1, 2013, to May 31, 2014, 53 patients were confirmed to be infected with the H7N9 virus; one was a retrospective case in Jiangsu province.
38 sequences of PB1 in H7N9 of Jiangsu were obtained from the GISAID online and were then divided into three lineages.
Of these sequences, 4 sequences and 3 sequences encode an N-terminally truncated PB1-F2 (52aa)polypeptide and C-terminally truncated PB1-F2 (76aa) polypeptide, respectively.
The remaining sequences encode a full-length PB1-F2 (90aa).
We estimated a mean evolutionary rate of 3.053 × 10−3 subs/site/year (95% HPD: 2.021 × 10−3–4.051 × 10−3).
The site-by-site analysis of selection pressure analysis revealed positively and negatively (12, 3), respectively, selected sites.
Influenza A (H7N9) virus adapting into new host, PB1-F2 of H7N9, might be faced with higher selection pressures.
American Psychological Association (APA)
Wei, Pingmin& Li, Wei& Zi, Hairong& Cunningham, Michael& Guo, Yan& Xuan, Yang…[et al.]. 2015. Epidemiological and Molecular Characteristics of the PB1-F2 Proteins in H7N9 Influenza Viruses, Jiangsu. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056783
Modern Language Association (MLA)
Wei, Pingmin…[et al.]. Epidemiological and Molecular Characteristics of the PB1-F2 Proteins in H7N9 Influenza Viruses, Jiangsu. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056783
American Medical Association (AMA)
Wei, Pingmin& Li, Wei& Zi, Hairong& Cunningham, Michael& Guo, Yan& Xuan, Yang…[et al.]. Epidemiological and Molecular Characteristics of the PB1-F2 Proteins in H7N9 Influenza Viruses, Jiangsu. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056783