Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling
Joint Authors
Pereira, Robyn D.
De Long, Nicole E.
Wang, Ruijun C.
Yazdi, Fereshteh T.
Holloway, Alison C.
Raha, Sandeep
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Proper placental development and function are central to the health of both the mother and the fetus during pregnancy.
A critical component of healthy placental function is the proper development of its vascular network.
Poor vascularization of the placenta can lead to fetal growth restriction, preeclampsia, and in some cases fetal death.
Therefore, understanding the mechanisms by which uterine stressors influence the development of the placental vasculature and contribute to placental dysfunction is of central importance to ensuring a healthy pregnancy.
In this review we discuss how oxidative stress observed in maternal smoking, maternal obesity, and preeclampsia has been associated with aberrant angiogenesis and placental dysfunction resulting in adverse pregnancy outcomes.
We also highlight that oxidative stress can influence the expression of a number of transcription factors important in mediating angiogenesis.
Therefore, understanding how oxidative stress affects redox-sensitive transcription factors within the placenta may elucidate potential therapeutic targets for correcting abnormal placental angiogenesis and function.
American Psychological Association (APA)
Pereira, Robyn D.& De Long, Nicole E.& Wang, Ruijun C.& Yazdi, Fereshteh T.& Holloway, Alison C.& Raha, Sandeep. 2015. Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056832
Modern Language Association (MLA)
Pereira, Robyn D.…[et al.]. Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056832
American Medical Association (AMA)
Pereira, Robyn D.& De Long, Nicole E.& Wang, Ruijun C.& Yazdi, Fereshteh T.& Holloway, Alison C.& Raha, Sandeep. Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056832